Biological Systems Modeling
Seyede Fatemeh Ghoreishian Amiri; Mohammad Pooyan
Volume 14, Issue 4 , February 2021, , Pages 321-331
Abstract
Parkinson's disease (PD) is a neurological disorder that mainly affects dopamine-producing neurons and motor system. The most obvious symptoms of PD are tremor, slow movement, stiffness and difficulty with walking. Walking in PD is slower than normal walking. In this paper, the gait in patients ...
Read More
Parkinson's disease (PD) is a neurological disorder that mainly affects dopamine-producing neurons and motor system. The most obvious symptoms of PD are tremor, slow movement, stiffness and difficulty with walking. Walking in PD is slower than normal walking. In this paper, the gait in patients with PD is modeled by a mathematical and computational method. This model includes structures which are involved in PD, such as basal ganglia, thalamus, cortex, supplementary motor area (SMA), muscle and joint-load dynamics. The output of the model is walking speed in PD. The output value is 0.83 m/s, which is in the range reported by clinical results (0.18-1.21 m/s). Some methods which increase the gait speed in PD are investigated too. These methods include deep brain stimulation, drug prescription and strengthening the muscles. The results show that each of these methods will improve the gait speed, in fact, by using these methods, the value of output increases and approaches the walking speed range in healthy individuals (1.36-1.30 m/s). Moreover, the effect of rigidity on gait speed is studied; it has been observed that the stiffness and speed of the gait are inversely related. Finally a control method is offered which improve the gait speed by increasing the magnitude response of the closed-loop system.
